Relationship Between Transforming Growth Factor ? 1 and Tumor Necrosis Factor ? with Liver Fibrosis in Chronic Viral Hepatitis Subjects
- VernacularTitle:慢性病毒性肝炎患者血清转化生长因子?_1、肿瘤坏死因子?水平与肝纤维化的关系
- Author:
Ren QIANG
;
Jianru XU
- Publication Type:Journal Article
- Keywords:
Viral hepatitis;
Liver cirrhosis;
Transforming growth factor ? 1;
Tumor necrosis factor ?
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the actions of transforming growth factor ? 1 (TGF-? 1) and tumor necrosis factor ?(TNF-?) in the liver fibrosis formation in chronic viral hepatitis patients and liver cirrhosis patients.Methods Serum levels of TGF-? 1 and TNF-? were measured by ELISA in 107 patients with chronic liver diseases,liver biopsy was performed in 23 patients in order to identify pathological stages under optic microscope.Results The serum levels of TGF-? 1(?g/L) in mild,middle and severe groups of chronic viral hepatitis and liver cirrhosis group were 14 2?5 9,20 1?7 0,30 2?6 7 and 32 6?7 5 respectively.The serum levels of TNF-? (pg/L) were 6 1?3 2,29 8?18 6,57 3?22 5 and 96 7?38 2 respectively.The serum levels of above two markers increased with hepatitis progression.The results of liver biopsy revealed that the changes in these two markers were related to liver cirrhosis degree.Conclusions TGF-? 1 and TNF-? are related to liver cirrhosis formation.
