Role of angiotensin Ⅱ in the regulation of platelet-derived growth factor receptor ? subunit of vascular smooth muscle
- VernacularTitle:血管紧张素Ⅱ对血管平滑肌血小板源生长因子受体?亚单位的调节
- Author:
Dongqi XING
;
Hua BAI
;
Yinping SUN
;
Jie LIU
;
Lilin WU
- Publication Type:Journal Article
- Keywords:
Angiotensin Ⅱ;
Platelet-derived growth factor;
Muscle, smooth, vascular
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the crosstalk between angiotensin Ⅱ (AngⅡ)-mediated and platelet-derived growth factor (PDGF)-mediated signal transduction in vascular smooth muscle proliferation.METHODS: A model of renal hypertension was made by two kidney/one-clip operation. Level of PDGF receptor ? subunit of aorta was measured by Western Blot analysis. The effect of Ang Ⅱ on PDGF receptor ? subunit expression was investigated in culture rat aortic vascular smooth muscle cells (VSMC).RESULTS: Systolic blood pressure obviously increased at 8th week after operation, whereas the level of PDGF receptor ? subunit of aorta significantly increased by 126.6% ( P
