Accumulation of p53 and cytokeratin-18neo in non-small cell lung cancer and its clinicopathological significance
- VernacularTitle:p53蛋白堆积和CK-18neo在非小细胞肺癌组织中的病理意义
- Author:
Yongyi LIU
;
Xueyun ZHONG
;
Yunxian CHEN
;
Hong SHEN
;
Zinen WANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Apoptosis;
Genes, p53;
Protein p53;
Antigenic determinants
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the tumorigenicity of lung cancer by learning the accumulation of p53 and the exposure of cytokeratin 18 neo-epitope(CK-18neo) related to the clinicopathological parameters in non-small cell lung cancer(NSCLC). METHODS: To detect the monoclonal antibodies of p53 and M 30 CytoDEATH(specific antibody for CK-18neo) in 62 cases of NSCLC (included 29 cases of squamous cell carcinoma and 33 cases of adenocarcinoma) and 10 cases of control group by adopting immunohistochemistry assay (LSAB). Moreover, the immunoreactivity of p53 was quantitatively evaluated with positive unit (PU). RESULTS: (1) p53 immunoreactivity was positive in 15 of 29 squamous cell carcinoma (51.72%), 15 of 33 adenocarcinoma (45.45%), 30 of 62 NSCLC (48.39%). In 10 control cases was negative. There were significant differences between these groups ( P
