Mycophenolic acid:a novel immunosuppressive drug
- VernacularTitle:霉吩酸:一种新型免疫抑制剂
- Author:
Hongliang LI
;
Xianda REN
;
Kaihe YE
- Publication Type:Journal Article
- Keywords:
Mycophenolic acid;
Purines;
Lymphocytes;
Immunosuppression
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Mycophenolate acid is a novel immunosuppressive drug. Its target of action is the isomerⅡof inosine 5'-monophosphate dehydrogenase(IMPDH). It inhibits de nove purine synthesis and also decreases expression of adhesive molecule. It inhibits selectively the proliferation of lymphocyte, so that it has strong immunosuppressive effects on various rejections to allograft or xenograft, and on autoimmune diseases, and has the features of higher potency and lower toxicity.[
