Experimental study on the cardiomyocyte apoptosis in the early myocardial ischemia
- VernacularTitle:早期心肌缺血心肌细胞凋亡的实验研究
- Author:
Bingjie HU
;
Jianguo CHEN
;
Xiaohu XU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Apoptosis;
Terminal deoxynucleotidyl transferase(TdT) mediated biotinylated dUTP nick end-labeling(TUNEL)
- From:
Chinese Journal of Forensic Medicine
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the significance of cardiomyocyte apoptosis in the early myocardial ischemia,the rat model of acute myocardial ischemia was established,and the apoptotic cells were detected in the early phase of ischemia(within 6h)with TUNEL method.The results showed that scanty apoptotic cells could be observed in the ischemic region 1h after ischemia,and reached the peak 3h after ischemia,then decreased.No apoptotic cells were found in the normal region.In the peri ischemic region,apoptotic cells could also be observed 1h after ischemia,and reached the peak 5h after ischemia.It is indicated that apoptosis is the major form of early ischemic myocardial damage,and the detection of apoptotic cardiomyocyte may provide a new sensitive and objective method for the postmortem diagnosis of early myocardial infarction.
