Activation of group I metabotropic glutamate receptors in rat striatum induces contralateral rotation
- VernacularTitle:大鼠纹状体I组代谢型谷氨酸受体激动引起动物向对侧旋转
- Author:
Fang YUAN
;
Zhongcheng WANG
;
Lixin XU
;
Tianyou WANG
;
Yazhu ZHANG
- Publication Type:Journal Article
- Keywords:
Glutamates;
Rotation;
Dopamine
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the subtype of metabotropic glutamate receptors (mGluRs) which induce contralateral rotations of rats after mGluRs activation. METHODS: Turning movement was measured at 6 h after agonist or antagonist of mGluRs was microinjected into rat striatum. RESULTS: tACPD, an agonist of mGluRs, at 500 nmol and 1 000 nmol induced contralateral rotations of rats. L-AP 3, MCPG and dantrolene attenuated the turning effect of tACPD. DHPG, a selective agonist of group I mGluRs, mimicked the effect of tACPD. The effect of DHPG was blocked by MCPG, LY367385 (antagonist of mGluR 1) and MPEP (antagonist of mGluR 5), and abolished by pretreatment with reserpine (5 mg/kg). CONCLUSION: These results indicated the activation of group I mGluRs in rat striatum induced turning effect, which may be associated with the mobilization of intracellular Ca 2+ stores and dependant on the existence of dopamine.
