Distribution and Pharmacokinetics of Lung Targeting Etoposide-bovine Serum Albumin-microspheres in Mice
- VernacularTitle:依托泊苷白蛋白微球小鼠体内分布及药代动力学
- Author:
Zhiqing ZHANG
;
Xiuling YANG
;
Li SUN
;
Sumin LI
;
Shumei WANG
;
Chuanping WANG
;
Jianming LEI
;
Dehou FAN
;
Junkang JIANG
- Publication Type:Journal Article
- Keywords:
VP-BSA-MS;
lung targeting;
distribution in vivo;
pharmacokinetics;
HPLC
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare etoposide-bovine serum albumin-microspheres (VP-BSA-MS)and to study the distribution and pharmacokinetics of VP-BSA-MS in mice. METHODS: The drug concentrations in various tissues were determined by high-performance liquid chromatograph (HPLC). RESULTS: The VP-BSA-MS was injected into mice and (47.88?2.56 )% of the total dosage was detected in lung tissue 15min after administration,the pharmacokinetical equation was C=149.0 897e-1.7 780t+3.9 627e-0.0 398t —153.0 524e-3.5 054t. CONCLUSION:The VP-BSA-MS showed remakable targeting action to the lung and the pharmacokinetic regularity could be discribed as two-compartment model
