A Case of Subcutaneous Panniculitic T-cell Lymphoma in a Child.
10.5021/ad.2004.16.1.31
- Author:
Hong Seok KIM
;
Ki Young HEO
;
Jin Yeong HAN
;
Jin A JUNG
;
Ki Hoon SONG
;
Ki Ho KIM
- Publication Type:Case Report
- Keywords:
Subcutaneous panniculitic T-cell lymphoma;
Cutaneous T-cell lymphoma;
Cytophagic histiocytic panniculitis;
Hemophagocytosis
- MeSH:
Abdomen;
Acute Kidney Injury;
Adipocytes;
Bone Marrow;
Cheek;
Child*;
Cyclophosphamide;
Dexamethasone;
Doxorubicin;
Drug Therapy;
Female;
Fever;
Glycogen Storage Disease Type VI;
Histiocytes;
Humans;
Lymphocytes;
Lymphoma, T-Cell*;
Lymphoma, T-Cell, Cutaneous;
Methotrexate;
Mitoxantrone;
Prednisolone;
T-Lymphocytes*;
Thorax;
Vincristine
- From:Annals of Dermatology
2004;16(1):31-38
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of subcutaneous panniculitic T-cell lymphoma (SPTCL) which occurred in a 10-year-old Korean girl. Her disease presented as multiple erythematous subcutaneous nodules on the right cheek, left chest, abdomen, left flank, both calves, and left shin with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 2 months often with spiking fever. Histopathologic findings for the subcutaneous nodules revealed lobular panniculitis-like findings composed of atypical small, bland lymphocytes and histiocytes. Characteristically, atypical lymphocytes rimmed individual fat cells in a lace-like pattern and some histiocytes occasionally phagocytosed WBCs. Bone marrow findings revealed increased phagocytic histiocytes with engulfed hematopoietic cell. The immunophenotypic studies showed CD45RO (UCHLl)+, CD20-, CD4-, CD8+ and CD56+ (focal), lysozyme+, CD45 (LCA)+ and EBV-. She received three cycles of high-dose cyclophosphamide, adriamycin, vincristine, prednisolone (CHOP) and methotrexate, intrathecal methotrexate and one cycle of fludarabine, mitoxantrone and dexamethasone (FND) chemotherapy. She died of acute renal failure during multiple chemotherapy.
