Effect of Estrogen Replacement Therapy on the Serum Nitric Oxide and Endothelin-1 Level of Ovariectomized Rats
- VernacularTitle:雌激素对去卵巢大鼠血清一氧化氮和内皮素水平的影响
- Author:
Shaodong YI
;
Yunjun RAN
;
Fengying DONG
- Publication Type:Journal Article
- Keywords:
Estrogen replacemen therapy;
Nitric oxide;
Endothelin-1;
Animal experiment;
Rat
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of estrogen replacement therapy on the serum nitric oxide and endothelin-1 level of ovariectomized rat.Methods The ovariectomized animal model and estrogen replacement therapy rat were established,thirty female rats were randomly divided into three groups:group A,ovariectomy;group B,ovariectomy plus estrogen replacement therapy;group C,sham-ovariectomy.The rats were killed after two months.The serum nitric oxide and endothelin-1 level were determined.Results In group A,the serum nitric oxide level was lower as compared with group C,but the serum endothelin-1 level was higher than those in group C.In group B,the serum nitric oxide level was higher and the serum endothelin-1 level was lower than those in group A.Conclusions Estrogen could modulate the productions of the nitric oxide and the endothelin-1 in the vascular endotheliocytes and improve the function of the vascular endothelial cells,which may be a bases of the benificial effect of estrogen in the prevention of atherosclerosis.
