The effect of urapidil on the plasma level of endothelin, neuropeptide Y and calcitonin gene-related pepitide in high-risk cardiac patients undergoing emergency noncardiac surgery
- VernacularTitle:高危心脏病患者血浆ET、NPY、CGRP含量变化以及乌拉地尔对其的影响
- Author:
Min LIANG
;
Li FANG
;
Aizhen WU
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Endothelins;
Neuropeptide Y;
Calcitonin gene related pepitide;
Urapidil
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the usefulness of urapidil in the management of high risk cardiac patients undergoing emergency noncardiac operation Methods 20 cardiac patients (male 11, female 9) scheduled for emergency noncardiac surgery were included in this study The age averaged (54 1?16 5) years The heart diseases included pregnancy induced hypertension(PIH) complicated with congestive heart failure(CHF) in 5 patients, coronary artery heart disease in 7, hypertensive heart disease in 4 and rheumatic heart disease in 4 Functionally they were classed as Ⅱ or Ⅲ according to New York Heart Association(NYHA) classification 40 healthy blood donors served as normal control In operating room before anesthesia the patients were given an intravenous bolus of urapidil 0 4 mg kg -1 Venous blood samples were taken before and 15 min after intravenous administration of urapidil for determination of plasma concentration of endothelin (ET) neuropeptide Y (NPY) and calcitonin gene related pepitide (CGRP) by radioimmunoassay Results Plasma concentrations of ET and NPY were significantly higher and CGRP was significantly lower in high risk cardiac patients than normal control values 15 min after urapidial ET and NPY decreased significantly (P
