Restricted expansion of T cell receptor (TCR)V? genes in leukemic patients subjected to allogeneic hematopoeitic stem cell transplantation
- VernacularTitle:白血病病人异基因外周血干细胞移植后淋巴细胞TCRV?基因片段的选择性扩增
- Author:
Xin DU
;
Yangqiu LI
;
Jianhua SU
;
Shunong LI
;
Wei LIN
;
Zilu HUANG
- Publication Type:Journal Article
- Keywords:
Genes;
Leukemia;
Hematopoietic stem cells;
Polymerase chain reaction
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate restricted expansion of TCR V? gene repertoire in patients with leukemia following allogeneic hematopoietic stem cell transplantation. METHODS: TCR V? subfamily genes in peripheral blood mononuclear cells from 7 cases of leukemia was amplified using RT-PCR. RESULTS: Only two-eight fragments of V? genes were detected in samples from these patients, and the detected fragments are different in different patients. CONCLUSION: TCR complexes were abnormal in all patients, part of the genes were seletively expansed and part of them were suppressed after transplantation.
