Effect of Qing-Kai-Ling Injecta on cAMP content of hypothalamus and AVP content in ventral septal area of endotoxin-induced febrile rabbits
- VernacularTitle:清开灵对内毒素性发热家兔下丘脑cAMP及腹中隔区AVP含量的影响
- Author:
Danhui ZHANG
;
Yufeng JIANG
;
Qifu HUANG
;
Xu JIA
;
Jing YAN
;
Xuey LU
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Fever;
Adenosine cyclic monophosphate;
Argipressin
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the mechanism of Qing-Kai-Ling(QKL) Injecta suppressing endotoxin(ET)-induced fever in rabbits.METHODS: ①The ET-induced fever model was established in rabbits. QKL injecta was administered intravenously, and the febrile response of rabbits was observed. The cAMP content in the hypothalamus (HP) and arginine vasopressin (AVP) content in the ventral septal area (VSA) were determined by radioimmunoassay.RESULTS: ①The maximal increment in body temperature (△T)[(1 68?0 46)℃],6 h thermal response index (TRI 6)(29 59?10 39), cAMP content in the HP[(2 90?0 40) nmol/g] and AVP content in the VSA[(47 32?3 77) ng/g] in the ET group were significantly higher than those in the normal saline (NS) group[(0 08?0 11)℃,-0.15?4 29,(1 05?0 37) nmol/g,(11 78?7 87) ng/g, respectively] and the QKL+ET group[(0 48?0 18)℃, (13.71?3.29), (1 37?0 23) nmol/g,(25 24?2 61) ng/g, respectively].②The positive correlation was observed between the cAMP content in the HP and the fluctuation of body temperature ( r=0.904,P
