Expression of intercellular adhesion molecule in lung tissues of experimental acute lung injury and the effect of rhubarb
- VernacularTitle:实验性急性肺损伤肺组织中细胞间粘附分子的表达及大黄对其影响
- Author:
Chunsheng LI
;
Peichun GUI
;
Xinhua HE
- Publication Type:Journal Article
- Keywords:
Lipopolysaccharides;
Lung;
Rhubarb;
Dexamethasone;
Cell adhesion molecules
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To approach the relationship between the expression of intercellular adhesion (ICAM-1 mRNA) and acute lung injury (ALI) as well as the mechanisms of rhubarb in the prevention and treatment of the lung injury. METHODS: ALI animal model was performed by Lipopolysaccharide (LPS). The rats were divided into 4 groups: LPS group, control group, rhubarb+LPS group and dexamethasone+LPS group. Histopathological examination and biological markers were measured for the lung specimens. Molecular hybridization method was used to determine the expression of ICAM-1 mRNA. RESULTS: The ICAM-1 mRNA expression in the lung tissues of LPS group significantly increased compared with control group ( P
