Study on the neuronal morphology of lymphostatic cerebroedema in rats
- VernacularTitle:淋巴滞留性脑水肿大鼠神经元形态改变的观察
- Author:
Yushe CHEN
;
Zuoli XIA
;
Mingfeng YANG
;
Pixin GONG
;
Danchu HAN
- Publication Type:Journal Article
- Keywords:
Rats;
Lymph;
Brain edema;
Neurons
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the pathological feature of neuron in the process of lymphostatic cerebro dema.METHODS: The model of lyphostatic cerebro edema was established by occluding and removing both the shallow and deep cervical lymph nodes in rats. The tissues of their brains were studied at different times after the operation, under light-microscope (HE stain and TUNEL stain) and electron-microscope.RESULTS: Cerebroedema appeared 2 days after the blockage of cervical lymphatic. Apoptosis and necrosis of neuron were observed in cerebral cortical of parietal lobus and hippocampal CA1 sector mainly. The alterations above were most noticeable at fifths day after the blockage. CONCLUSION: The blockage of the drainage of the cerebral lymphatic can lead to lymphastatic cerebroedema. Neuronal apoptosis and necrosis was the main pathological feature in the brain.
