Signal transduction of transforming growth factor-? family and tumor
- VernacularTitle:转化生长因子—?族信号转导与肿瘤
- Author:
Ping ZHANG
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta;
Signal transduction;
Neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Cytokines of the transforming growth factor (TGF-?)family exert multiple biological effects by their signal transduction pathways that undergo a basic course of ligands of TGF-? family→receptors→SMADs→transcription factors→DNA expression. The genetic variety of different signal molecules in transduction pathways of TGF-? family were found in various benign or malignant tumors, and this had much significance in designing effective therapeutic strategy.
