Expression of Inducible Nitric Oxide Synthase and NF-? Bp65 in Patients with P soriasis Vulgaris and Their Clinical Significance
- VernacularTitle:寻常型银屑病患者皮肤中诱生型一氧化氮合酶、核因子-?Bp65表达及其临床意义
- Author:
Zheng YANG
;
Haiquan WEN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Nitric oxide synthase;
NF-kappa B
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the internal relationship between the exp ression of inducible nitric oxide synthase (iNOS) and the activation of NF-? B p65 in the skin of patients with psoriasis vulgaris(PV) and their roles in the p athogenesis of PV. Methods The expression and distribution of iNOS and NF-? Bp 65 were studied by in situ hybridization and immunohistochemistry in 20 patients with PV and 12 healthy controls. The severity of PV was assessed by Psoriasis a nd Severity Index(PASI) score. Results① The expression of both iNOS mRNA and pr otein was significantly higher in lesional epidermis than those in non lesiona l epidermis and epidermis of the controls (P