Expression of Inducible Nitric Oxide Synthase and NF－? Bp65 in Patients with P soriasis Vulgaris and Their Clinical Significance
- VernacularTitle:寻常型银屑病患者皮肤中诱生型一氧化氮合酶、核因子-?Bp65表达及其临床意义
- Author:
Zheng YANG
;
Haiquan WEN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Nitric oxide synthase;
NF－kappa B
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the internal relationship between the exp ression of inducible nitric oxide synthase (iNOS) and the activation of NF－? B p65 in the skin of patients with psoriasis vulgaris(PV) and their roles in the p athogenesis of PV. Methods The expression and distribution of iNOS and NF－? Bp 65 were studied by in situ hybridization and immunohistochemistry in 20 patients with PV and 12 healthy controls. The severity of PV was assessed by Psoriasis a nd Severity Index(PASI) score. Results① The expression of both iNOS mRNA and pr otein was significantly higher in lesional epidermis than those in non lesiona l epidermis and epidermis of the controls (P
