Study on Complement and Activated Complement Factors in Peripheral Blood and Ski n in Patients with Psoriasis
- VernacularTitle:银屑病患者血清及皮肤中补体及其活化成分的变化
- Author:
Guizhi WANG
;
Haiyan ZHOU
;
Chengyu LIU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Complement
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of complement and activated co mplement factors in peripheral blood and skin in patients with psoriasis and the ir significance in the development of psoriatic lesion. Methods Enzyme linked im munosorbent assay (ELISA) and immuno turbidi metric analysis were used to dete rmine the levels of C3d, sC5b－9, C3 and C4 in sera from 57 patients with psori asis vulgaris. Immunohistochemistry was employed to assess in situ expression of SC5b－9 in lesional and non lesional skin of 37 patients. Results There was a significant decrease of C3 and C4, and increase of C3d and sC5b－9 in patient s with psoriasis in comparison with those of normal controls (t=10.88～ 24.80, P
