Protection of nitric oxide for hepatic steatosis caused by total parenteral nutrition in rats
- VernacularTitle:一氧化氮对全胃肠外营养肝脂肪变性的保护作用
- Author:
Jinfang ZHENG
;
Lijian LIANG
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Parenteral nutrition, total;
Fat necrosis
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the effect of nitric oxide(NO) on hepatic steatosis caused by total parenteral nutrition(TPN) in ratsMethods Thirty Wistar rats were randomly divided into five groups: Group A, normal control; Group B, TPN group;Group C, TPN plus L arginine; Group D, TPN plus N G nitrio L arginine methyl ester(L NAME,NOS inhibitor); Group E, TPN plus L arginine and L NAME. At the seventh day, liver function tests were performed and the livers were resected to test the lipid and nitric oxide content, and nitric oxide synthase activity.[WT5”HZ] Results [WT5”BZ] The hepatic lipid content 〔triglycerid(?mol/g), cholesterol(?mol/g)〕in group B significantly increased compared with group A (39 3?2 4、13 1?1 1 vs. 6 9?0 8、5 6?0 6)( P
