Effect of ?-interferon on the expresson of Fas, Bcl-2 on Hep-G2 hepatocellular carcinoma cells
- VernacularTitle:?-干扰素对肝癌细胞株Hep-G2 Fas,Bcl-2表达的影响
- Author:
Yansong ZHENG
;
Yongkun LIN
;
Xinsheng LU
;
Zheng SHI
- Publication Type:Journal Article
- Keywords:
INTERFERON/pharmaco;
GENES EXPRESSION/drug eff;
GENE,FAS;
GENE,Bcl-2;
TUMOR CELLS,CULTURED/drug eff;
CELL LINE,TRANSFORMED/drug eff;
APOPTOSIS;
CARCINOMA,HEPATOCELLCILAR
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of ?-interferon (?-IFN) on liver cancer cell line (Hep-G2). Methods Observing the expression of Fas and Bcl-2 by ?-IFN-pretreated Hep-G2 cells via immunohistochemical stain; subsequently treating these cells with adrimysin, and observing the cell death rate and apoptosis of these cell by MTT and electroscopy. Results (1) ?-IFN up-regulating the expression of Fas protein and down-regulating Bcl-2 protein (P
