The Surgical Effect of Callosotomy in the Treatment of Intractable Seizure.
10.3349/ymj.2004.45.2.233
- Author:
Dong Seok KIM
1
;
Kook Hee YANG
;
Tae Gon KIM
;
Jong Hee CHANG
;
Jin Woo CHANG
;
Joong Uhn CHOI
;
Byung In LEE
Author Information
1. Department of 1Neurosurgery and 2Neurology, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. juchoi@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Intractable seizure;
callosotomy;
disconnection syndrome;
generalized seizure;
drop attack
- MeSH:
Adolescent;
Adult;
Child;
Corpus Callosum/*surgery;
Electroencephalography;
Epilepsy, Generalized/pathology/*surgery;
Female;
Human;
Magnetic Resonance Imaging;
Male;
Prognosis;
Treatment Outcome
- From:Yonsei Medical Journal
2004;45(2):233-240
- CountryRepublic of Korea
- Language:English
-
Abstract:
We evaluated the surgical effects of the callosotomy, particularly with respect to the effect of callosotomy in some seizure types and the extent of surgery. Twenty-one patients with a minimum follow-up of two year were enrolled. The most significant effect of callosotomy was the complete suppression of the generalized seizures associated with drop attack in 12 of 21 patients and seizure reduction of more than 75% in 6 of 21 patients. The surgical effect on the partial seizures was very variable. Transient disconnection syndrome appeared in 4 patients after anterior callosotomy. Total callosotomy by staged operation significantly suppressed generalized seizures associated with drop attack without any disconnection syndrome. Our data show that callosotomy is quite a good approach to the surgical treatment of drop attacks accompanied by disabling generalized seizures.
