Changes of somatosensory evoked potential,serum and brain nitric oxide levels and effect of Ginkgo Biloba extract following subarachnoid hemorrhage in rats
- VernacularTitle:蛛网膜下腔出血大鼠体感诱发电位和一氧化氮含量变化及银杏叶制剂的影响(英文)
- Author:
Baoliang SUN
;
Zuoli XIA
;
Mingfeng YANG
;
Pingming QIU
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Cerebral ischemia, transient;
Electrophysiology;
Nitric oxide;
Drugs, Chinese herbal
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of somatosensory evoked potential(SEP), nitric oxide (NO) levels both in serum and in brain tissue after subarachnoid hemorrhage(SAH) and the influence of Ginkgo biloba extract(GBE) on them. METHODS: Wistar rats were divided into sham-operated group, pure SAH group and GBE-treated group. Dynamic changes of regional cerebral blood flow( rCBF),SEP, and NO levels both in serum and in brain tissue were detected within 24 hours after operation. RESULTS: In pure SAH group, rCBF decreased immediately after operation, with no tendency to recover within 24 hours. Latency of SEP delayed progressively from 1 hour to 24 hours after SAH.NO levels in serum and in brain tissue decreased and increased respectively from 1 hour to 24 hours after SAH. GBE effectively antagonized the changes of above parameters. CONCLUSION: SEP is useful in the judgement of cerebral ischemic damage after SAH. Decrease of serum NO and increase of brain NO are important factors leading to cerebral vasospasm and neural damage respectively after SAH. GBE relieves cerebral ischemic damage by reversing the pathological alterations of NO.
