The anti-inflammatory mechanisms of ?-melanocyte-stimulating hormone
- VernacularTitle:?-黑色素细胞刺激素的抗炎机制
- Author:
Bo CHEN
;
Chaofeng HU
;
Huadong WANG
;
Chen LIN
;
Chuji LI
- Publication Type:Journal Article
- Keywords:
MSH;
Cytokines;
NF-kappa B;
Inflammation
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
?-MSH is an endogenous neuropetide that is effective of all categories of expreimental inflammation. The mechanisms underlying the anti-inflammatory influence of ?-MSH are reviewed in the article. ?-MSH suppresses inflammation in the CNS and periphery by downregulating the activation of NF-?B, then inhibiting production of proinflammatory cytokines, nitric oxide, chemokines and adhension molecules, and increasing synthesis of anti-inflammatory cytokines. ?-MSH is useful in the treatment of many pathological situations in humans.
