Analysis of the genetic polymorphisms of the STR  TPOX locus in two populations and study on three rare genes

VernacularTitle:TPOX基因座三个基因的检出及遗传多态性分析
Author: Baojie WANG ; Mei DING ; Dong ZHAO
Publication Type:Journal Article
Keywords: TPOX locus; Genetic polymorphism; STR
From: Chinese Journal of Forensic Medicine 1986;0(01):-
CountryChina
Language:Chinese
Abstract: The polymorphisms of the TPOX locus in two population were studied by PCR technique followed by the denatured PAGE and silver staining.Seven alleles were detected in each population of 100 unrelated Northern Chinese Han individuals and 93 unrelated African(Xhosa)individuals in South Africa respectively.No deviation from the Hardy Weinberg equilibrium was demonstrated.The power of discrimination(DP)and the exclusion probability(EPP)were 0 7978 and 0 4625;0 9141 and 0 6125 respectively.Comparison of gene frequency distribution showed that there is significant difference between different races.In addition,three rare genes were detected in we Africans(Xhosa)individuals.Sequencing proved that the only difference among them was the number of repeat unit in the region amplified by the specific primer pair.It might be due to the unequal exchange between chromosomes which was resulting in the production of a chimera.Our study showed that the TPOX locus has a high discriminating power which is important for the study of forensic medicine and human genetics\;