The expression and significance of the cell cycle related genes in uveal melanoma
- VernacularTitle:细胞周期相关基因在葡萄膜黑色素瘤中的表达与意义
- Author:
Linjie GUO
;
Zhongyao WU
;
Huling ZHENG
- Publication Type:Journal Article
- Keywords:
Uveal neoplasms/physiopathology;
Melanoma/physiopathology;
Cell cycle;
Immunohistochemistry
- From:
Chinese Journal of Ocular Fundus Diseases
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of the cell cycle related genes cyclinD1 and Bcl-2 protein expression in the pathogenesis and infiltration of the uveal melanoma. Methods Using immunohistochemistry to detect the cyclinD1 and bcl-2 protein expression in 96 cases of uveal melanoma. Results The expression content of bcl-2 was high in uveal melanoma, and there wasnt any relationship between bcl-2 cell positivity and tumor cell type and extrascleral extension. In contrast, cyclinD1 expression was higher in epithelial cell uveal melanoma than mix cell and spindle cell varieties. There was a positive correlation between cyclinD1 cell positivity and extrascleral extension. Conclusion The expression of bcl-2 protein is important for the survival of the uveal melanoma. CyclinD1 may serve as a sensitive index of its malignancy.
