The effect of intercellular adhesion molecule-1 monoclonal antibody on microcirculation of burn shock in rats
- VernacularTitle:ICAM-1单抗对烧伤休克大鼠微循环的影响
- Author:
Xuliang HUANG
;
Xiangbing WU
;
Chunhua JIN
;
Kesen ZHAO
- Publication Type:Journal Article
- Keywords:
Antibodies, monoclonal;
Shock;
Burns;
Microcirculation
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To detect the effect of intercellular adhesion molecule-1(ICAM-1) monoclonal antibody on microcirculation disorder in burn shock of Wistar rats. METHODS: The blood flow velocity and diameter of venule were measured with RBC tracking correlator and IV550 model video microscaler in burn shock models of rats. The number of leukocytes adhered on venule wall was calculated under microscope. The animal survival time was observed. RESULTS: ICAM-1monoclonal antibody could attenuate the falling of mean arterial pressure, significantly reduce the number of leukocytes adhered on venule wall, and obviously prolong the animal mean survival time, but less than 24h. CONCLUSION: ICAM-1 monoclonal antibody can decrease the number of adhered leukocytes to endothelial cells, attenuate the tether of leukocytes to venule and improve microcirculation and protect tissue cells in burn shock of rats. However, a comprehensive therapy should be taken in severe shock.
