The comparative study on SiNi-decoction and VitE against oxidative injury of vascular endothelial function and their preventive and therapeutic action on experimental atherosclerosis in rabbits
- VernacularTitle:四逆汤与维生素E抗血管内皮功能氧化损伤及防治家兔实验性动脉粥样硬化的比较研究
- Author:
Heqing HUANG
;
Weikang WU
;
Hanchuan LUO
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Endothelium, vascular;
Wounds and injuries;
Drugs, Chinese herbal;
Vitamin E
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare effects of SiNi-decoction and Vitamin E on vascular endothelial function of experimental atherosclerosis rabbits and their therapeutic action on atherosclerosis. METHODS: The model of experimental atherosclerosis rabbits fed with forage of high lipid was established and treated in groups randomly. At the end of the experiment, samples of aorta and blood were taken and the percentage of lipid plaque area of aortic endothelium ,lipid metabolism and vascular endothelial oxidative injury (SOD activity, MDA content, NO level, endothelin concentration) of each group were analyzed. RESULTS: In comparison with model group,the percentage of the lipid plaque area of aortic endothelium and endothelial oxidative injury (except for SOD of VitE group) of SiNi-high and mid-dose group and VitE group are reduced obviously (P
