Study on re-warm ischemia-reperfusion injury of the cold-preserved livers and its mechanism
- VernacularTitle:兔肝冷保存后复温缺血-再灌注损伤及其相关机制的研究
- Author:
Lijun TANG
;
Fuzhou TIAN
;
Yu WANG
;
Xiaojun LI
;
Darong HUANG
;
Jianzhong HU
- Publication Type:Journal Article
- Keywords:
Rabbits;
Liver transplantation;
Free radicals;
Ischemia;
Reperfusion injury
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the value of donor liver re-warm ischemia-reperfusion injury during orthotopic liver transplantation and its mechanism. METHODS: The effect of rabbit liver re-warm ischemia on its reperfused liver function and change of malondialdehyde(MDA) and superoxide dismutase(SOD) in the hepatic tissue were observed with rabbit liver preservation-reperfusion injury model . RESULTS: In every group of donor livers, which had experienced re-warm ischemia for 0, 15, 30 and 60 minutes respectively following 6-hours cold storage,the more prolonged re-warm ischemia was, the higher the contents of blood AST, ALT and AKP of receptor rabbits would be, and among all the groups there was significant difference in the contents of AST or ALT or AKP(P
