Effect of cystic fibrosis transmembrane conductance regulator gene mutation on male fertility
- VernacularTitle:囊性纤维变性跨膜调节器基因突变对男性生殖的影响
- Author:
Chenxi ZHOU
;
Xi WANG
;
Zidong WANG
;
Won PYD
- Publication Type:Journal Article
- Keywords:
Cystic fibrosis;
Fertility;
Epididymis
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Large number of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations are responsible for a wide spectrum of disease expressions in CF (cystic fibrosis). They includs not only the malfunction of the lung and pancreas, intestinal obstruction, and incapable of salt reabsorption, but also some kinds of male infertility, such as congenital bilateral absence of the vas deferens (CBAVD),poor sperm quality, the obstruction and agenesis of the epididymis. More recent studies have indicated that CFTR gene mutations have a far-reaching effect on human reproduction.
