Levels of sTNFR、 TNF? in Serum and PBMC Culture Medium Supernatants of Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者可溶性肿瘤坏死因子受体及肿瘤坏死因子?水平的研究
- Author:
Kaiming ZHANG
;
Xiaoying YANG
;
Xingping YIN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic Receptors, tumor necrosis factor Tumor necrosis factor alpha
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the levels of soluble tumor necrosis factor receptor (sTNFR)、 tumor necrosis factor alpha(TNF? ) in systemic lupus erythematosus(SLE) patients and its clinical significance. Methods Double antibody sandwich ELISA was used to determine soluble tumor necrosis factor receptor typeⅠ (sTNFRⅠ )、 soluble tumor necrosis factor receptor typeⅡ (sTNFRⅡ ) and TNF? levels in patient serum and peripheral blood mononuclear cell(PBMC) culture supernatants. Other immunological tests were carried out simultaneously. Results① The serum sTNFRⅠ、 sTNFRⅡ、 TNF? sTNFRⅠ /TNF? and sTNFRⅡ /TNF? ratios were significantly higher in SLE patients than those in normal control group(P
