Effects of UVB and UV irradiated UCA on the Function of Langerhans′ Cell
- VernacularTitle:紫外线及其辐射的尿刊酸对朗格汉斯细胞功能影响的研究
- Author:
Yanhua LI
;
Zhigang BI
;
Yi JIANG
- Publication Type:Journal Article
- Keywords:
Ultraviolet rays Urocanic acid Langerhans cells Immunosuppression
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunosuppression mechanism induced by ultraviolet (UV) and cis urocanic acid. Method The auto lymphocyte proliferation test with Langerhans′ cell (LC) in guinea-pig was performed. Results In exposure to low dose of UVB (25 J/m2) radiation, the inhibition rate of lymphocyte proliferation stimulated by LC was 10.5％ , the inhibition rates of UVB radiation in doses of 50 J/m2 and 100 J/m2 were 22.4％ or 50％ , respectively. The lymphocyte proliferation was almost completely suppressed by 200 J/m2 UVB radiation, while the inhibition of LC function by cis urocanic acid was weak. Conclusion UVB significantly inhibits LC auto-stimulation in dose-dependent way, which may play an important role in UVB induced immunosuppression.
