A preliminary study on the correlation between gastric lymphoid follicles and Helicobacter pylori infection
- VernacularTitle:胃粘膜淋巴滤泡与幽门螺杆菌关系探讨
- Author:
Zhiquan ZHAO
;
Wei ZHANG
;
Hongjie ZHANG
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Lymphoid follicles;
cagA gene
- From:
Chinese Journal of Digestive Endoscopy
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between H.pylori strain possessing cagA gene and the formation of gastric lymphoid follicles(GLF),and the effect of H.pylori infection on the occurrence of GLF.Methods Antral biopsy specimens from 655 patients (chronic gastritis:n=479,peptic ulcer:n=176)were used for detection of H.pylori infection and histological analysis. CagA gene was examined in 70 clinical isolates by means of PCR－ amplification. Results The incidence of lymphoid follicles in gastric mucosa is significantly higher(60.14％ ) in patients with H.pylori infection than those without infection(17.06％ ).GLF is easier to be detected in patients with active gastritis than in those with inactive gastritis. There is no significant difference in the presence of GLF among H.pylori associated gastroduodenal diseases,such as chronic gastritis ,gastric ulcer. Moreover, there is also no significant relationship between H.pylori strains possessing cagA gene and GLF. Conclusion The presence of GLF might directly related with H.pylori infection, and can be observed as a constant morpholgical marker of H.pylori related gastroduodenal disease ;The formation of gastric lymphoid follicles is not related to the cytotoxin of cag A gene of H.pylori.
