Plasma Total Homocysteine and Influential Factors in Hemodialysis Patients
- VernacularTitle:血液透析病人血浆总同型半胱氨酸水平及其影响因素
- Author:
Qingfeng HAN
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
Homocysteine;
MTHFR gene
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Objective In order to investigate plasma total homocysteine(tHCY) level,its influential factors,and the relationship between total homocysteine(tHCY)and N 5,N 10 -methylenetetrahydrofolate reductase(MTHFR) gene in hemodialysis patients.Method Pre-and posthemodialysis plasma tHCY and MTHFR genotype were measured by high performance liquid chromatography(HPLC) method and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method respectively,and dialysis related indexes were detected simultaneously.Results Plasma tHCY in hemodialysis patients was(28 4?5 8)?mol/L,and it was significantly higher than normal control(P
