Role of Fas Mediated Cells Apoptosis in Pathogenesis of Human Colonic Cancer Tissue
- VernacularTitle:Fas介导的细胞凋亡在结肠癌发生机制中的作用
- Author:
Yaojun WANG
;
Ziqing SUN
;
Qizhen QUAN
- Publication Type:Journal Article
- Keywords:
Colonic neoplasm;
Apoptosis;
Fas gene
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of Fas gene expression in pathogenesis of human colonic cancer tissue.Method Expression of Fas gene protein in benign and malignant colonic tissue was detected by using flow cytometry in forty patients.Results Expression rate of Fas in normal control mucosas was(12 17?3 68)%.The expression rate in colonic cancer tissue was lower than both normal control group and benign tissue.The expression rate in inflammatory tissue was higher than the normal mucosal tissue,and the expression rate was correlated with the tumor differentiation.Conclusions Fas-mediated apoptosis may play an important role in carcinogenesis of colonic tissue.
