A clinical study on effects of propofol or isoflurane anesthesia on sodium nitroprusside-induced hypotension
- VernacularTitle:异丙酚和异氟醚麻醉对硝普钠控制性降压的影响
- Author:
Wentao SONG
;
Shanglong YAO
;
Guangxing BAO
- Publication Type:Journal Article
- Keywords:
Propofol;
Isoflurane;
Nitroprusside;
Hypotension,controlled
- From:
Chinese Journal of Anesthesiology
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of propofol anesthesia on hemodynamic changes and dose requirement of sodium nitroprusside (SNP) during SNP-induced hypotension.Methods Sixteen patients undergoing elective microneurosurgery were randomly assigned to one of two groups: propofol group and isoflurane group. In propofol group (n=8) anesthesia was maintained with propofol (infusion rate 100?g?kg -1?min -1 ) after dural opening, whereas in isoflurane group (n=8) anesthesia was maintained with 1.3 MAC isoflurane.After 20 min the MAP of both groups was reduced by 40% with continuous infusion of 0.01% SNP solution.Results Blood pressure was more easily reduced and maintained in propofol group, and was lower in propofol group than that in isoflurane group following SNP withdrawl (P
