The effect of nitric oxide inhalation on surfactant depletion-induced acute lung injury in piglet
- VernacularTitle:吸入NO对肺灌洗诱导的急性肺损伤家猪血液动力学及肺气体交换的影响
- Author:
Chan SUN
;
Ji GU
- Publication Type:Journal Article
- Keywords:
Bronchoalveolar lavage;
Respiratory distress syndrome;
Nitric oxide;
Hemodynamics
- From:
Chinese Journal of Anesthesiology
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of inhalation of 20ppm nitric oxide(NO) on gas exchange and hemodynamics in acute lung injury induced by surfactant depletion in piglet.Methods Sixteen female piglets weighing 25-30 kg were induced with thiopental and pancuronium and maintained with continuous infusion of thiopental,fentanyl and pancuronium. The animals were tracheotomized and mechanically ventilated with oxygen(FiO 2=1.0). Femoral artery was cannulated for arterial blood sampling and blood gas analysis.Pulmonary catheter was inserted through the femoral vein for measurement of CVP, mean pulmonary artery pressure(MPAP), PCWP, cardiac output (CO) and sampling of mixed venous blood. Acute lung injury was induced by lung lavage after the method described by Lachmann until PaO 2 was lower than 100mm Hg(PaO 2/FiO 2
