Effects of ketamin and midazolam on serum TNF-? and myocardial cAMP in septic shock rats
- VernacularTitle:氯胺酮-咪唑安定对感染性休克大鼠血清肿瘤坏死因子-?和心肌环磷酸腺苷的影响
- Author:
Hong XIAO
;
Quanyun WANG
;
Lan ZHANG
- Publication Type:Journal Article
- Keywords:
Shock,septic;
Tumor necrosis factor;
Cyclic AMP;
Ketamine;
Midazolam
- From:
Chinese Journal of Anesthesiology
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). TNF-? in group EK and EKM was lower than that in group E (P0.05). Conclusions Ketamine can inhibit the release of TNF-? caused by LPS and increase myocardial cAMP level, protecting myocardium from sepsis. This may be one of the anti-septic shock mechanisms of ketamine. Combination of midazolam with ketamine does not affect the anti-septic shock property of ketamine.
