The effect of ?-amyloid protein on the behaviors and SOD activity and MDA content of hippocampus in D-galactose-induced aging rats
- VernacularTitle:?-淀粉样蛋白对D-半乳糖致衰大鼠行为及海马SOD活性和MDA含量的影响
- Author:
Ya LI
;
Haiqiang QIN
;
Qishen CHEN
- Publication Type:Journal Article
- Keywords:
Amyloid beta-protein;
Alzheimer's disease;
Aging;
Learning;
Memory
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of ?-amyloid protein (?-AP) and D-galactose(D-gal) on learning-memory and SOD activity and MDA content of hippocampus in rats. METHODS: The behaviors of rats were measured by using open field, Y-maze and one-trial passive avoidance response, and the content of SOD and MDA were measured. RESULTS: In the D-gal and D-gal+?-AP group rats, the spontaneous activities and responses to novel environment in the open field were significantly decreased, and the abilities of learning-memory were remarkably attenuated, the content of SOD decreased and MDA content increased markedly in hippocampus (P
