Changes in IGF-I levels in serum and pulmonary arterioles of rats with hypoxic pulmonary hypertension
- VernacularTitle:低氧大鼠血清和肺小动脉壁胰岛素样生长因子-I的变化
- Author:
Yong LIN
;
Wenbin CHEN
;
Deyun CHENG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Hypertension, pulmonary;
Insulin-like growth factor Ⅰ
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study changes in IGF-I concentration in serum, IGF-I polypeptide in the wall of pulmonary arterioles during hypoxia and the relationship between their changes and hypoxic pulmonary hypertension. METHODS: Morphological change in pulmonary arterioles was determined by image pattern analysis technique, the concentration of IGF-I in the rat serum was measured by radioimmunoassay. The expression of IGF-I polypeptide was observed by immunohistochemical staining on the walls of pulmonary arterioles, and analyzed quantitatively. RESULTS: After exposing hypoxia for 3 weeks, mPAP of rats was elevated(P
