Role of angiotensin Ⅱ receptors in overload pressure-induced left ventricular hypertrophy
- VernacularTitle:血管紧张素Ⅱ受体在压力超负荷致左室肥大中的作用
- Author:
Ping ZHANG
;
Guoxiang HE
;
Guochao WANG
;
Luxiang CHI
- Publication Type:Journal Article
- Keywords:
Receptors, angiotensin;
Hypertrophy, left ventricular
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To investigate the role of angiotensin Ⅱ recepters(ATRs) in overload pressure-induced left ventricular hypertrophy. The rat abdominal aortic constraction model was adopted. At 10th week after operating, angiotensin Ⅱ in myocardium was measured by radioimmunoassay,tissue ATRs and its subtype were analysed by radioligand binding assay. RESULTS: The AngⅡ content in the operated group was significantly higher than that of the control group, LVMI was positively correlated with AngⅡ(r=0.8066,P
