Effects of Liqustrazin on respiratory enzymes in the myocardial mitochondria of the ischemia-reperfusion rats
- VernacularTitle:川芎嗪对缺血再灌注损伤心肌重要呼吸酶的影响
- Author:
Fusheng WAN
;
Bo LIU
;
Xiaoman ZHAO
;
Zhaojian ZENG
- Publication Type:Journal Article
- Keywords:
Ligusticum chuanxiong hort;
Myocardial reperfusion injury;
Succinate dehydrogenase;
Cytochrome C oxidase
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of Liquestrazin on succinic dehydrogenase (SDH) and cytochrome oxidase (CCO) in the myocardial mitochondria of the ischemia-reperfusion rats and its mechanism. METHODS:Model of myocardial ischemia-reperfusion injury was produced by coronary artery ligation . The rats were devided into sham operation control (SC), ischemia-reperfusion (IR) and ischemia-reperfusion protected with Liqustrazin (IR+L) group . Activity of SDH,CCO,SOD and GSH?PX and contents of malondialdehyde (MDA),Cyt aa 3,Cyt c and phospholipid(PL) were observed respectively . RESULTS: As compared with ischemia-reperfusion group (IR), IR+L group showed significantly increased activity of SDH, CCO,SOD and GSH?PX (P
