The role of radionuclide imaging in evaluation of both functional and structural changes of the graft after orthotopic liver transplantation
- VernacularTitle:放射性核素肝胆显像在评估移植肝功能和结构变化中的作用
- Author:
Hui CAO
;
Zhiyong WU
;
Xiaojie ZHANG
- Publication Type:Journal Article
- Keywords:
WT5”BZ] Liver transplantation;
Radionuclide;
Rats
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective[WT5”BZ] To evaluate the role of radionuclide 99m Tc EHIDA for hepatobiliary imaging in rats with orthotopic liver transplantation (OLT) [WT5”HZ]Methods[WT5”BZ] Male SD rats were divided into 2 groups: normal controls (NL, n =10)and normal rats with OLT (NL OLT, n =8). Dynamic scintigraphy using single photon emission computed tomography (SPECT) was used for hepatobiliary imaging. [WT5”HZ] Results[WT5”BZ] The time of peak activity (t max ) and half peak activity(t 1/2 ) in the liver and intestine (GI) imaging time (min) in NL and 6 uncomplicated NL OLT rats were 3 05?0 31 vs. 3 63?0 65 ( P 0 05), respectively. The time active curves and imaging of NL OLT rats were similar to that in NL rats.The t max and t 1/2 in the liver, GI imaging time and the time active curves in 2 complicated NL OLT rats were significantly different compared with that of NL rats. Radionuclide leak occurred in 1 NL OLT rat.[WT5”HZ] Conclusions [WT5”BZ] Radionuclide 99m Tc EHIDA effectively monitors both structural and functional changes of the liver graft. [WT5”HZ]
