The Inhibitory Effect of Dihydro-?-erythroidine on Nicotine Induced-current in Cultured Sympathetic Neurons
- VernacularTitle:二氢-?-刺桐啶碱对交感神经元烟碱诱发电流的抑制作用
- Author:
Wei LIU
;
Jianquan ZHENG
;
Zhenwei LIU
;
Lijun LI
;
Chuanhui LIU
- Publication Type:Journal Article
- Keywords:
whole-cell recording;
induced-current;
dihydro-?-erythroidine;
superior cervical ganglion cell;
nicotinic receptor;
competitive antagoni
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the inhibitory effect of dihydro-?-erythroidine on nicotine induced-current in cultured superior cervical ganglion of neonatal rats.METHODS:Pneumatic pressure administration of drug and whole-cell recording techniques were performed to compare induced-current amplitude.RESULTS:Dihydro-?-erythroidine competitively antagonized nicotinic effect,and EC50 was about 0.015mmol/L.CONCLUSION:Dihydro-?-erythroidine is a competitive antagonist of nicotinic receptors in sympathetic neurons.
