The effects of glycyl-glutamine enriched TPN on the small intestinal graft
- VernacularTitle:甘氨酰谷氨酰胺对移植小肠的营养支持作用
- Author:
Yousheng LI
;
Jianwen JIANG
;
Ning LI
- Publication Type:Journal Article
- Keywords:
WT5”BZ] Transplantation,autologous;
Glutamine;
Parenteral nutrition, total
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective [WT5”BZ] To evaluate the effects of glycyl glutamine (Gly Gln) on the small intestinal graft. [WT5”HZ]Methods [WT5”BZ] Ten outbrid pigs undergoing small bowel autotransplantation were randomly divided into 2 groups. In STPN group, the animals received standard TPN devoid of Gly Gln,and in GTPN group,the animals received isonitrogenous (0 3?g?kg -1 ?d -1 )and isocaloric (nonprotein calory:137 9?kJ?kg -1 ?d -1 ) TPN with 2% Gly Gln.Animals were fed for 28 days. [WT5”HZ]Results [WT5”BZ] At the end of TPN,the mucosal contents of Gln (1 14?0 20)??mol/g tissue wet weight, protein (101?22)?mg/g and the villous contents of DNA (3 84?0 39) and RNA (3 31?0 14),the graft villous height (308?52) ?m, surface area (0 154?0 019) mm 2 and mucosal thickness(665?72) ?m were significantly higher in the GTPN group than that in STPN group ( P
