Association of human papillomavirus 16 and its serum antibody in gastric carcinoma
- VernacularTitle:人乳头瘤病毒16及其血清抗体与胃癌相关性的研究
- Author:
Guanbao ZHU
;
Lifang ZHANG
;
Jun CHENG
- Publication Type:Journal Article
- Keywords:
WT5”BZ] Stomach neoplasms;
Papillomavirus;
Antibodies
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective [WT5”BZ] To study the relationship between human papillomavirus (HPV) 16 and its serum antibody in the development of gastric carcinoma (GC) [WT5”HZ] Methods [WT5”BZ] Polymerase chain reaction (PCR) technique was used to detect HPV DNA in 42 fresh GC specimens and 42 fresh normal gastric mucosa adjacent to the tumour (NGMAT). Enzyme linked immunosorbent assay (ELISA) was used to screen the serum HPV16 antibody(Ab) of 42 GC patients and 46 controls using HPV16 virus like particles (VLPs) which was produced by recombinant bacilovirus in insect cells [WT5”HZ] Results [WT5”BZ] HPV16 DNA was found in 26 2% (11/42) of GC specimens,but in none (0/42) of NGMAT ( P
