Effects of lofexidine on the pharmacokinetics of morphine in rats
- VernacularTitle:洛非西定对大鼠吗啡药代动力学的影响研究
- Author:
Yujin WANG
;
Jialing ZHANG
;
Keming YUN
- Publication Type:Journal Article
- Keywords:
Morphine Lofexidine Pharmacokinetics RadioimmunoassayL
- From:
Chinese Journal of Forensic Medicine
1988;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetics of morphine in rats was studied after treatment with morphine, as well as morphine and lofexidine. The results showed that in lofexidine group the T 1/2ka and CL of morphine was significantly increased, while the C max ,AUC and T 1/2k of morphine were significantly decreased. Our results indicate that the lofcxidine can reduce the absorption rate of the morphine and the concentration of morphine in blood, and then can increase the total clearance rate of morphine in rats.
