Perioperative changes in tumor necrosis factor-alpha, superoxide dismutase, lipid peroxides and creatine kinase MB in arterial and coronary sinus blood in patients undergoing heart valves replacement
- VernacularTitle:心脏瓣膜置换术围术期动脉血及冠脉血TNF-?、SOD、LPO及CK-MB的变化
- Author:
Tianlong WANG
;
Deshui YU
;
Jingfan ZHANG
- Publication Type:Journal Article
- Keywords:
Heart valve diseases;
Cardiopulmonary bypass;
Tumor necrosis factor alpha;
Superoxide dismutase;
Lipid peroxides;
Creatine kinase isoenzymes
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine perioperative changes of tumor necrosis factor alpha (TNF ?),superoxide dismutase(SOD),lipid peroxides(LPO) and creatine kinase MB (CK MB) in patients undergoing cardiopulmonary bypass (CPB) Methods Thirteen patients undergoing heart valves surgery were studied Blood samples were taken from artery and coronary sinus for measurement of plasma TNF ? and LPO concentrations, and plasma SOD and CK MB activities prior to CPB, 5min,30min after aorta declamping, at the end of operation, 6h and 18h after surgery respectively Blood gas analysis was done at various intervals and alveolar arterial oxygen gradient (P A a DO 2) was calculated The net myocardial release of TNF ? (coronary sinus plasma level minus arterial level) was recorded Results Arterial and coronary sinus TNF? levels increased significantly following aortic declamping as compared with those before CPB and were kept at the higher level till the end of operation (P
