Myocardial protective effects of thoracic epidural anesthesia with ropivacaine during acute myocardial ischemia reperfusion
- VernacularTitle:罗哌卡因胸段硬膜外阻滞对急性心肌缺血/再灌注损伤的保护作用
- Author:
Gang LI
;
Yongguang XU
;
Huizhen LIU
- Publication Type:Journal Article
- Keywords:
Anesthesia, epidural;
Myocardial reperfusion injury;
Troponin T;
Ropivacaine
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the myocardial protective effects of thoracic epidural anesthesia (TEA) with 0 5% ropivacaine during acute myocardial ischemia reperfusion Methods Eighteen healthy hybrid dogs were randomly divided into three groups: ropivacaine group (group Ⅰ), bupivacaine group (group Ⅱa) and normal saline group (group Ⅱb) Anesthesia was induced and maintained with intravenous anesthesia and ventilation was mechanically controlled Epidural catheter was placed at T 6 7 and 0 5% ropivacaine, 0 5% bupivacaine or normal saline 12ml was administered epidurally 15min after epidural administration of local anesthetics or normal saline, the anterior descending branch of left coronary artery was temporarilly occluded for 45min Blood samples were taken from right atrium and assayed for cardiac troponin T (cTnT) before epidural administration and 6h after reperfusion Myocardial tissues of left ventricular infarction area were examined by electron microscopy Results Plasma cTnT levels were comparable (P
