Relationship between Angiotensin Converting Enzyme Gene Polymorphism and Serum Angiotensin Converting Enzyme Activity
- VernacularTitle:血管紧张素转换酶基因多态性与血清血管紧张素转换酶活性关系
- Author:
Huaxin LIU
;
Zhengli LUO
- Publication Type:Journal Article
- Keywords:
Angiotensin converting enzyme;
Polymorphism;
Genotype
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the relationship between angiotensin converting enzyme(ACE) gene polymorphism and angiotensin converting enzyme activity,the polymerase chain reaction(PCR) was used to detect an insertion/deletion(I/D) polymorphism of ACE gene in its sixteenth intron.The genotype,enzyme coupling spectrophotometry were used to measure serum ACE activity among the three genotypes.Results showed that the Serum ACE activities were (337 6?92 0),(292 7?76 5 )and(243 5?58 9)u/L for genotypes DD,ID and ⅠⅠ respectively.The findings indicate that the ACE gene polymorphism closely associated with serum ACE activity.
