Detection of Telomerase Activity in Gastric Mucosa by Improved TRAP Assay
- VernacularTitle:改良TRAP法检测胃粘膜标本端粒酶活性
- Author:
Yong WU
;
Zhengyan CHEN
- Publication Type:Journal Article
- Keywords:
Gastric tumor,cancer;
Telomerase;
Laboratory diagnosis;
Gastric mucosa biopsy
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Telomerase activity in 43 biopsy of gastric mucosa was detected with the modified telomeric repeat amplification protocol(TRAP) assay to elucidate pathogenesis of gastric cancer.The detected positive rates were as follows:87%(20/23) in gastric cancer,28 6%(2/7) in moderate and non-typical gastritis ,0%(0/10 in atrophic and superficial gastritis,respectively.These results suggest that the detection of telomerase activity may play a significant role in the diagnosis of gastric cancer.
