Glutamate transport across blood brain barrier after transient global ischemia/reperfusion in rats
- VernacularTitle:大鼠短暂全脑缺血再灌后谷氨酸透过血脑屏障的变化
- Author:
Xiaodong LIU
;
Guoqing LIU
- Publication Type:Journal Article
- Keywords:
Glutamates;
Blood-brain barrier;
Cerebral ischemia, transient;
Reperfusion
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: to study the change of glutamate(Glu) transport across blood brain barrier(BBB) in rat following forebrain ischemia/reperfusion. METHODS: BBB unidirectional transfer constant(K i) for [3H]-Glu in rat hippocampus, cerebral cortex and striatum were determined after rats were subjected to cerebral ischemia 10 min (two-carotid occlusion plus hypovolemic hypotension) followed by 0.17, 2, 6 and 24 h of reperfusion. The recovery of [3H]-Glu in cerebrum was also determined after intracerebral injection of [3H]-Glu in another experiment. RESULTS: Compared with control rat brain, K i for [3H]-Glu significantly(P
